Blood Pressure Medication Affects Unconscious Addiction Memories

There is still a lot that scientists do not understand about the complex nature of addiction. Nevertheless, researchers continue to tirelessly probe the human mind in order to decode the nature of addiction and the causes of relapse, with the hope that one day better treatments for the disease can be developed.

Over the last few years, addiction researchers have been testing the effects of a number pharmaceuticals developed for a series of medical conditions. The goal was to see if such drugs had an impact on the cycle of addiction. Researchers from the University of Texas at Austin have been experimenting with the blood pressure medication isradipine, and if human trials prove successful, the drug could help prevent relapse, ScienceDaily reports.

The researchers gave high doses of the antihypertensive drug isradipine to rats addicted to cocaine or alcohol. Hitoshi Morikawa, an associate professor of neuroscience at The University of Texas at Austin, along with colleagues, trained rats to associate either a black or white room with the use of a drug, according to the article. Over time, the rats given isradipine no longer chose the room they associated with the addictive drug. The rats who didn’t receive the antihypertensive almost always choice the drug room. The findings suggest that the memories of addiction had disappeared entirely.

"The isradipine erased memories that led them to associate a certain room with cocaine or alcohol," said Morikawa.

It may be possible to target the associations an addict has with the experience prior to the use of a drug. If isradipine can erase the unconscious memories that underlie addiction in humans, it would be a monumental advancement in addiction research.

"Addicts show up to the rehab center already addicted," he said. "Many addicts want to quit, but their brains are already conditioned. This drug might help the addicted brain become de-addicted."

The Food and Drug Administration (FDA) has approved isradipine, the article reports. Morikawa points out that clinical trials could begin in the near future.

The findings were published in the journal Molecular Psychiatry.

If you are or a love one are in the grips of a substance use disorder, please contact Harmony Foundation. We can help you build a foundation for recovery.
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Addiction and recovery news provided by Harmony Foundation

A Review of Medical Marijuana Research

The need for a better understanding of marijuana’s medicinal properties is great, considering that more states are expected to adopt medical marijuana programs in the coming years. There are currently 23 states and the District of Columbia which have active medical marijuana programs. Such programs have brought on an increase in research involving the controversial drug. While each state is different regarding the acceptable health conditions for which marijuana can be recommended, new research suggests that cannabis works for treating some conditions better than others, Reuters reports.

A new review of previously conducted research, which included 80 randomized trials involving nearly 6,500 people, indicated moderate support for using cannabis to treat certain ailments, including chronic pain, muscle spasms and involuntary movements. However, the review did not show much support for using cannabis to treat:

• Chemotherapy Induced Nausea and Vomiting
• Sleep Disorders
• HIV-Related Weight Loss
• Tourette Syndrome

"As systematic reviewers, we have provided a summary of the available evidence which doctors can now use to make decisions regarding whether to prescribe cannabinoids for their patients," said Penny Whiting of University Hospitals Bristol NHS Foundation Trust in the UK. 

Whiting points out that when considering the benefits of using marijuana to treat medical conditions, one must also consider the potential side effects which often accompany the drug, according to the article. Side effects which include:

• Euphoria
• Dry Mouth
• Dizziness
• Nausea
• Sleepiness

"Individuals considering cannabinoids as a possible treatment for their symptoms should discuss the potential benefits and harms with their doctor," said Whiting. 

The research was published in the Journal of the American Medical Association (JAMA).

It is important to keep in mind that marijuana is a mind altering substance which carries with it the potential for addiction. If you find yourself struggling with cannabis, please do not hesitate to reach out for help.
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Addiction and recovery news provided by Harmony Foundation

Prescription Drug Overdose Deaths Rise in 26 States

In a number of states, especially the ones hardest hit by prescription opioid abuse, drastic measure have been taken to curb the problem. While such efforts have shown promise, such as prescription drug monitoring programs and greater access to naloxone, many states are still seeing a rise in overdose deaths. New research suggests that the number of drug overdose deaths rose in 26 states between 2009 and 2013, Reuters reports. Only six states saw a decrease in overdose deaths during the same time period.

The study was conducted by the nonprofit group Trust for America’s Health and the Robert Wood Johnson Foundation. Their findings indicated that an estimated 44,000 Americans died from drug overdoses in 2013, a figure which is more than double the number found in 1999. Drug overdoses were responsible for more deaths in 36 states than motor vehicle-related deaths, according to the article.

In 2013, almost 52 percent of overdose deaths were related to prescription drugs. The two types of prescription drugs that were linked to the majority of overdoses were opioid painkillers and benzodiazepine anti-anxiety medications, such as OxyContin ® (oxycodone) and Xanax ® (alprazolam). The study found that more than 16,000 deaths were related to opioids and almost 7,000 were tied to benzodiazepines and sleep medications.

The report clearly shows the need for more access and training to the life saving overdose reversal drug naloxone, sold under the brand name Narcan ®. There are 34 states and D.C. which have laws in place to expand access to, and use of, naloxone, according to the study. 

Prescription Drug Abuse Treatment 

If you are currently struggling with prescription drugs, and are need of help, please do not hesitate to contact Harmony Foundation to begin the journey of recovery. Harmony is a state-of-the-art, affordable, residential addiction treatment program located in the Rocky Mountains.
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Prevalence of Alcohol Use Disorders in America

In the United States, alcohol use disorders (AUDs) affect millions of people each year, more than any other mental health disorder. While alcohol is the most commonly used mind altering substance, the number of people with an AUD who actually seek help is quite low. New research suggests the between 2012-13 there were approximately 32.6 million people with AUDs, but only 7.7 percent sought treatment for their illness, JAMA Psychiatry reports. 

 

 What is an Alcohol Use Disorder (AUD)? 

The medical diagnosis of “alcohol use disorder” is given when problem drinking becomes severe. In order to be diagnosed as having AUD, individuals must meet certain criteria outlined by the Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5). In the 5th edition some changes were made to the criteria of AUDs, including:

• The elimination of separate abuse and dependence diagnoses.
• The combination of the criteria into a single alcohol use disorder diagnosis.
• The elimination of legal problems as an indicator.
• The addition of craving to the criteria.
• A diagnostic threshold of at least two criteria.
• The establishment of a severity metric based on the criteria count, i.e. mild, moderate, or severe.

 

The Prevalence of AUDs in America 

Researcher Bridget F. Grant, Ph.D., of the National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Institutes of Health, Bethesda, MD., and coauthors analyzed data from the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC)-III, according to the article. The total sample size was 36,309 adults.

The researchers found that, under the DSM-5, the 12-month prevalence of AUDs was 13.9 percent and the lifetime prevalence was 29.1 percent. The finding represents approximately 32.6 million and 68.5 million adults, respectively. Only 7.7 percent of people with an AUD over a 12-month period sought treatment, and only 19.8 percent of adults with lifetime AUDs sought help.

 

Young Adults With AUDs 

The study showed that the prevalence of AUDs was highest among male respondents (17.6 percent 12-month prevalence, 36 percent lifetime prevalence), as well as who those who were younger (26.7 percent 12-month prevalence, 37 percent lifetime prevalence).

"Most importantly, this study highlighted the urgency of educating the public and policy makers about AUD [alcohol use disorder] and its treatments, destigmatizing the disorder and encouraging among those who cannot reduce their alcohol consumption on their own, despite substantial harm to themselves and others, to seek treatment," the study concludes.

 

Alcohol Use Disorder Treatment 

If you are a young adult struggling with alcohol, and potentially meet the criteria of an alcohol use disorder, we encourage you to take a look at our Young Adult Recovery Track. Our program focuses on the specific needs of young people looking to find a new way of life through recovery.
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Addiction and recovery news provided by Harmony Foundation